Format

Send to:

Choose Destination
See comment in PubMed Commons below
Antimicrob Agents Chemother. 2009 Jun;53(6):2636-7. doi: 10.1128/AAC.01415-08. Epub 2009 Mar 16.

Regulation of mprF in daptomycin-nonsusceptible Staphylococcus aureus strains.

Author information

  • 1LA Biomedical Research Institute at Harbor-UCLA, 1124 West Carson Street, RB-2, Rm 230, Torrance, CA 90502, USA. sjyang@labiomed.org

Abstract

We used a well-characterized isogenic set of clinical bloodstream Staphylococcus aureus strains to study (i) regulation of mprF-mediated phosphatidylglycerol lysinylation in the contexts of in vitro daptomycin (DAP) nonsuceptibility and (ii) the role of mprF mutation in endovascular virulence. We observed a correlation between increased expression of a mutant mprF gene and reduced in vitro DAP susceptibility. There were no detectable fitness differences between strains in experimental infective endocarditis.

PMID:
19289517
[PubMed - indexed for MEDLINE]
PMCID:
PMC2687189
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Write to the Help Desk