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Bioorg Med Chem Lett. 2009 Apr 15;19(8):2154-7. doi: 10.1016/j.bmcl.2009.02.119. Epub 2009 Mar 4.

Ganoderic acid DM: anti-androgenic osteoclastogenesis inhibitor.

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  • 1Department of Forest and Forest Products Science, Faculty of Agriculture, Kyushu University, Fukuoka, Japan.


Prostate cancer is the most common cancer in men in Western countries, with a high incidence of bone metastasis. Ganoderic acid DM, with 5alpha-reductase inhibitory and androgen receptor (AR) binding activity, isolated from the ethanol extracts of Ganoderma lucidum, can inhibit prostate cancer cell growth and block osteoclastogenesis.

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