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    Bioorg Med Chem Lett. 2009 Apr 15;19(8):2154-7. Epub 2009 Mar 4.

    Ganoderic acid DM: anti-androgenic osteoclastogenesis inhibitor.

    Liu J, Shiono J, Shimizu K, Kukita A, Kukita T, Kondo R.

    Source

    Department of Forest and Forest Products Science, Faculty of Agriculture, Kyushu University, Fukuoka, Japan.

    Abstract

    Prostate cancer is the most common cancer in men in Western countries, with a high incidence of bone metastasis. Ganoderic acid DM, with 5alpha-reductase inhibitory and androgen receptor (AR) binding activity, isolated from the ethanol extracts of Ganoderma lucidum, can inhibit prostate cancer cell growth and block osteoclastogenesis.

    PMID:
    19289282
    [PubMed - indexed for MEDLINE]

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