Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Biophys J. 2009 Mar 18;96(6):L39-41. doi: 10.1016/j.bpj.2009.01.005.

Rigidity-dependent cross talk between integrin and cadherin signaling.

Abstract

Integrin-cadherin cross talk is an important aspect of cell function. We explored this signaling using substrates micropatterned with islands of fibronectin surrounded by E-cadherin, capturing the segregation of these signals in normal tissue. While MDCK cells were able to concurrently form adhesive structures with these two proteins, engagement of fibronectin by MCF-7 cells, an adenocarcinoma cell line, inhibited response of these cells to E-cadherin. We further demonstrated that this inhibition is rigidity dependent; on soft elastomer substrates with Young's modulus in the range of tens of kiloPascals, MCF-7 cells were able to engage both integrin and cadherin ligands.

PMID:
19289031
[PubMed - indexed for MEDLINE]
PMCID:
PMC2717266
Free PMC Article

Images from this publication.See all images (3)Free text

Figure 1
Figure 2
Figure 3
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk