Nat Rev Microbiol. 2009 Apr;7(4):274-86.

Pathogenic neisseriae: surface modulation, pathogenesis and infection control.

Source

Department of Cellular and Molecular Medicine, School of Medical Sciences, University Walk, University of Bristol, Bristol, BS8 1TD, UK. M.Virji@bristol.ac.uk

Abstract

Although renowned as a lethal pathogen, Neisseria meningitidis has adapted to be a commensal of the human nasopharynx. It shares extensive genetic and antigenic similarities with the urogenital pathogen Neisseria gonorrhoeae but displays a distinct lifestyle and niche preference. Together, they pose a considerable challenge for vaccine development as they modulate their surface structures with remarkable speed. Nonetheless, their host-cell attachment and invasion capacity is maintained, a property that could be exploited to combat tissue infiltration. With the primary focus on N. meningitidis, this Review examines the known mechanisms used by these pathogens for niche establishment and the challenges such mechanisms pose for infection control.

PMID:: 19287450; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Grant Support

Publication Types

MeSH Terms

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Supplemental Content

Save items

Related citations in PubMed

Molecular and biological analysis of eight genetic islands that distinguish Neisseria meningitidis from the closely related pathogen Neisseria gonorrhoeae. [Infect Immun. 2000]
Molecular and biological analysis of eight genetic islands that distinguish Neisseria meningitidis from the closely related pathogen Neisseria gonorrhoeae.
Klee SR, Nassif X, Kusecek B, Merker P, Beretti JL, Achtman M, Tinsley CR. Infect Immun. 2000 Apr; 68(4):2082-95.
Comparative genomics identifies the genetic islands that distinguish Neisseria meningitidis, the agent of cerebrospinal meningitis, from other Neisseria species. [Infect Immun. 2002]
Comparative genomics identifies the genetic islands that distinguish Neisseria meningitidis, the agent of cerebrospinal meningitis, from other Neisseria species.
Perrin A, Bonacorsi S, Carbonnelle E, Talibi D, Dessen P, Nassif X, Tinsley C. Infect Immun. 2002 Dec; 70(12):7063-72.
Identification of regions of the chromosome of Neisseria meningitidis and Neisseria gonorrhoeae which are specific to the pathogenic Neisseria species. [Infect Immun. 1999]
Identification of regions of the chromosome of Neisseria meningitidis and Neisseria gonorrhoeae which are specific to the pathogenic Neisseria species.
Perrin A, Nassif X, Tinsley C. Infect Immun. 1999 Nov; 67(11):6119-29.
Review Interaction of pathogenic neisseriae with nonphagocytic cells. [Clin Microbiol Rev. 1995]
Review Interaction of pathogenic neisseriae with nonphagocytic cells.
Nassif X, So M. Clin Microbiol Rev. 1995 Jul; 8(3):376-88.
Review [Factors in the pathogenicity of Neisseria]. [Zh Mikrobiol Epidemiol Immunob...]
Review [Factors in the pathogenicity of Neisseria].
Kostiukova NN, Mironova TK. Zh Mikrobiol Epidemiol Immunobiol. 1983 Mar; (3):3-9.

See reviews... See all...

Cited by 26 PubMed Central articles

The adaptor molecule Nck localizes the WAVE complex to promote actin polymerization during CEACAM3-mediated phagocytosis of bacteria. [PLoS One. 2012]
The adaptor molecule Nck localizes the WAVE complex to promote actin polymerization during CEACAM3-mediated phagocytosis of bacteria.
Pils S, Kopp K, Peterson L, Delgado Tascón J, Nyffenegger-Jann NJ, Hauck CR. PLoS One. 2012; 7(3):e32808. Epub 2012 Mar 20.
Structure of the C-terminal domain of Neisseria heparin binding antigen (NHBA), one of the main antigens of a novel vaccine against Neisseria meningitidis. [J Biol Chem. 2011]
Structure of the C-terminal domain of Neisseria heparin binding antigen (NHBA), one of the main antigens of a novel vaccine against Neisseria meningitidis.
Esposito V, Musi V, de Chiara C, Veggi D, Serruto D, Scarselli M, Kelly G, Pizza M, Pastore A. J Biol Chem. 2011 Dec 2; 286(48):41767-75. Epub 2011 Sep 29.
Pathogenic Neisseria hitchhike on the uropod of human neutrophils. [PLoS One. 2011]
Pathogenic Neisseria hitchhike on the uropod of human neutrophils.
Söderholm N, Vielfort K, Hultenby K, Aro H. PLoS One. 2011; 6(9):e24353. Epub 2011 Sep 16.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Pathogenic neisseriae: surface modulation, pathogenesis and infection control.
Pathogenic neisseriae: surface modulation, pathogenesis and infection control.
Nat Rev Microbiol. 2009 Apr ;7(4):274-86.

PubMed
A germline JAK2 SNP is associated with predisposition to the development of JAK2...
A germline JAK2 SNP is associated with predisposition to the development of JAK2(V617F)-positive myeloproliferative neoplasms.
Nat Genet. 2009 Apr ;41(4):455-9. Epub 2009 Mar 15 .

PubMed
p53-cofactor JMY is a multifunctional actin nucleation factor.
p53-cofactor JMY is a multifunctional actin nucleation factor.
Nat Cell Biol. 2009 Apr ;11(4):451-9. Epub 2009 Mar 15 .

PubMed
Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-i...
Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals.
Nature. 2009 Apr 2 ;458(7238):636-40. Epub 2009 Mar 15 .

PubMed
Surgical considerations in the management of falcotentorial meningiomas: advanta...
Surgical considerations in the management of falcotentorial meningiomas: advantages of the bilateral occipital transtentorial/transfalcine craniotomy for large tumors.
Neurosurgery. 2009 May ;64(5 Suppl 2):260-8; discussion 268.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: