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J Rheumatol. 2009 May;36(5):943-6. doi: 10.3899/jrheum.080764. Epub 2009 Mar 13.

Plasma 25,OH vitamin D concentrations are not associated with rheumatoid arthritis (RA)-related autoantibodies in individuals at elevated risk for RA.

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  • 1Department of Epidemiology, Colorado School of Public Health, University of Colorado Denver, Denver, Colorado, USA.



To evaluate the association between rheumatoid arthritis (RA)-related autoantibodies and plasma 25,OH vitamin D in subjects at risk for RA.


In 1210 subjects without RA, 76 were positive for anti-cyclic citrullinated peptide antibodies or for at least 2 rheumatoid factors (RF; by nephelometry: RF-IgM, RF-IgG, RF-IgA). 25,OH vitamin D was measured in these cases and 154 autoantibody-negative controls from this cohort.


25,OH vitamin D levels did not differ between cases and controls (adjusted OR 1.23, 95% CI 0.93-1.63).


Vitamin D concentrations are not associated with RA-related autoimmunity in unaffected subjects at increased risk for RA.

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