Successful desensitization by glargine administration in a patient with insulin allergy: a case report

Masumi Hara; Yoshihiko Izumida; Nobuhiro Sato; Ken Ohashi; Jun-ichi Osuga; Kazuyuki Tobe; Kazuhisa Tsukamoto; Takashi Kadowaki

doi:10.1016/j.diabres.2009.02.016

Successful desensitization by glargine administration in a patient with insulin allergy: a case report

Diabetes Res Clin Pract. 2009 Jun;84(3):e48-9. doi: 10.1016/j.diabres.2009.02.016. Epub 2009 Mar 14.

Authors

Masumi Hara¹, Yoshihiko Izumida, Nobuhiro Sato, Ken Ohashi, Jun-ichi Osuga, Kazuyuki Tobe, Kazuhisa Tsukamoto, Takashi Kadowaki

Affiliation

¹ Department of Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. masumihara-tky@umin.ac.jp

PMID: 19286270
DOI: 10.1016/j.diabres.2009.02.016

Abstract

The patient was a 56-year-old man with type 2 diabetes and insulin allergy. He was administered glargine, which did not produce any allergic reactions, except for a small non-pruritic wheal. Thereafter, other insulin preparation could be administered. We consider this the first case of successful insulin desensitization by glargine administration.

Publication types

Case Reports

MeSH terms

Desensitization, Immunologic / methods*
Diabetes Mellitus, Type 2 / blood
Diabetes Mellitus, Type 2 / drug therapy*
Diabetes Mellitus, Type 2 / immunology
Dose-Response Relationship, Drug
Drug Hypersensitivity / diagnosis*
Glycated Hemoglobin / metabolism
Humans
Insulin / administration & dosage
Insulin / adverse effects
Insulin / analogs & derivatives*
Insulin / therapeutic use
Insulin Glargine
Insulin, Isophane / adverse effects
Insulin, Isophane / therapeutic use
Insulin, Long-Acting
Male
Middle Aged

Substances

Glycated Hemoglobin A
Insulin
Insulin, Long-Acting
Insulin Glargine
Insulin, Isophane