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Am J Obstet Gynecol. 2009 Jun;200(6):645.e1-5. doi: 10.1016/j.ajog.2009.01.014. Epub 2009 Mar 16.

Vulvar cancer in young women: demographic features and outcome evaluation.

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  • 1Section of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.

Abstract

OBJECTIVE:

The objective of the study was to identify prognostic and environmental factors associated with vulvar carcinoma in young women.

STUDY DESIGN:

This study was a review of patients younger than 45 years who were diagnosed with vulvar squamous cell carcinoma between 1994 and 2006.

RESULTS:

Fifty-six patients were identified. Median age was 38 years and median follow-up was 25.3 months. Fifty-eight percent of patients presented with stage I disease; 77% smoked tobacco. Of patients with advanced disease, 53.3% were smokers, 40% had human papillomavirus (HPV) exposure, 46.7% had a history of vulvar intraepithelial neoplasia (VIN), and 6.7% were immunocompromised. Symptoms were present for more than 12 months in 47%, but symptom duration did not correlate with stage (P = .42) or positive lymph nodes (P = .28). Disease recurred in 10.7% and 5.4% died of disease.

CONCLUSION:

Young women with vulvar cancer tend to have early-stage disease, smoke, have a history of HPV, and have VIN. Many of the factors that place these patients at continuous risk are modifiable.

Comment in

PMID:
19286150
[PubMed - indexed for MEDLINE]
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