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Biosens Bioelectron. 2009 May 15;24(9):2804-9. doi: 10.1016/j.bios.2009.02.007. Epub 2009 Feb 20.

Novel U-bent fiber optic probe for localized surface plasmon resonance based biosensor.

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  • 1School of Biosciences and Bioengineering, IIT Bombay, Mumbai 400076, India.


The aim of this study is to develop an optical absorbance based biosensor suitable for wide scale use in resource-poor locales. A sensor for sensitive measurement of refractive index (RI) with the help of optical absorbance properties of gold nanoparticles (GNP) coupled to an efficient optical transducer in the form of a U-bent fiber optic probe is described. A U-bent probe was fabricated by a simple procedure. The absorbance due to the localized surface plasmon resonance (LSPR) of fiber-bound GNP was found to be linear to refractive index changes between 1.33 and 1.35. A U-bent probe of 200 microm diameter with a bend radius of 0.75 mm gave rise to a sensitivity of 35 DeltaA/RIU at 540 nm. The resolution of the sensor probe was 3.8x10(-5) RIU. Label-free biosensing was demonstrated using these probes with the help of IgG-anti IgG as bioreceptor-analyte pair.

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