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Biologicals. 2009 Jun;37(3):128-32. doi: 10.1016/j.biologicals.2009.02.006. Epub 2009 Mar 12.

Vaccine production in Neurospora crassa.

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  • 1Neugenesis Corporation, Burlingame, CA, USA.


We have chosen to use the filamentous fungus Neurospora crassa to produce subunit vaccines. Here we describe the production and purification of Influenza hemagglutinin and neuraminidase antigens in N. crassa. The N. crassa system used by Neugenesis offers many advantages over other systems for production of recombinant protein. In contrast to mammalian cell culture, N. crassa can be grown in a rapid and economic manner, generating large amounts of recombinant protein in simple, defined medium. Vaccines, therefore, can be produced more rapidly and at lower cost than conventional cell culture or egg-based systems. This has important applications to tailoring the seasonal vaccine supply and responding to new pandemics.

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