Am J Med Sci. 1991 Sep;302(3):157-62.

The role of the matrix metalloproteinase stromelysin in the progression of squamous cell carcinomas.

Matrisian LM, McDonnell S, Miller DB, Navre M, Seftor EA, Hendrix MJ.

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Department of Cell Biology, Vanderbilt University, Nashville, Tennessee 37232.

Abstract

The expression of the metalloproteinase stromelysin correlates with the progression of chemically induced squamous cell carcinomas. We demonstrate that the expression of activated stromelysin in papilloma-derived cells enhances in vitro cell invasion. We also demonstrate that the Ha-ras oncogene induces the transcription of the stromelysin gene through an AP-1 dependent pathway. The hypothesis is that alterations in oncogenes and suppressor genes influence stromelysin expression and thus influence subsequent steps of tumor invasion and metastasis.

PMID:: 1928226; [PubMed - indexed for MEDLINE]

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