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Clin Gastroenterol Hepatol. 2009 Jun;7(6):706-708.e1. doi: 10.1016/j.cgh.2009.02.023. Epub 2009 Mar 10.

A very low-carbohydrate diet improves symptoms and quality of life in diarrhea-predominant irritable bowel syndrome.

Author information

  • 1Division of Gastroenterology and Hepatology, University of Colorado Denver, 12631 East 17th Avenue, Room 7609, Aurora, Colorado 80045, USA. gregory.austin@uchsc.edu

Abstract

BACKGROUND & AIMS:

Patients with diarrhea-predominant irritable bowel syndrome (IBS-D) anecdotally report symptom improvement after initiating a very low-carbohydrate diet (VLCD). This study prospectively evaluated a VLCD in IBS-D.

METHODS:

Participants with moderate to severe IBS-D were provided a 2-week standard diet, then 4 weeks of a VLCD (20 g carbohydrates/d). A responder was defined as having adequate relief of gastrointestinal symptoms for 2 or more weeks during the VLCD. Changes in abdominal pain, stool habits, and quality of life also were measured.

RESULTS:

Of the 17 participants enrolled, 13 completed the study and all met the responder definition, with 10 (77%) reporting adequate relief for all 4 VLCD weeks. Stool frequency decreased (2.6 +/- 0.8/d to 1.4 +/- 0.6/d; P < .001). Stool consistency improved from diarrheal to normal form (Bristol Stool Score, 5.3 +/- 0.7 to 3.8 +/- 1.2; P < .001). Pain scores and quality-of-life measures significantly improved. Outcomes were independent of weight loss.

CONCLUSIONS:

A VLCD provides adequate relief, and improves abdominal pain, stool habits, and quality of life in IBS-D.

Comment in

PMID:
19281859
[PubMed - indexed for MEDLINE]
PMCID:
PMC2693479
Free PMC Article

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