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Clin Biochem. 2009 Jul;42(10-11):1064-70. doi: 10.1016/j.clinbiochem.2009.02.025. Epub 2009 Mar 10.

Altered amino acid homeostasis in subjects affected by fibromyalgia.

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  • 1Department of Internal Medicine, Division of Rheumatology, University of Pisa, Via Roma 67, 56126 Pisa, Italy. l.bazzichi@int.med.unipi.it

Abstract

OBJECTIVES:

To evaluate plasma amino acid (AA) concentrations in patients affected by fibromyalgia (FM) and to study the relationships between their levels and FM clinical parameters.

DESIGN AND METHODS:

20 AAs were assessed in 34 FM patients and in 18 healthy volunteers by means of a modified version of the Waters picotag method.

RESULTS:

Significant lower plasma taurine, alanine, tyrosine (Tyr), valine, methionine, phenylalanine and threonine concentrations, and the sum of essential AAs were observed in FM patients vs healthy controls (P<0.05). Tyr CAA' ratio and the sum of AAs competing with tryptophan for brain uptake were significantly reduced in FM (P<0.05). A significant correlation was found between FM clinical parameters and certain AAs.

CONCLUSIONS:

Our results suggest probable defects of gut malabsorption of certain AAs in FM patients. Moreover, given the reduced Tyr CAA' ratio in FM patients, a possible impairment of the cathecolaminergic system in the FM syndrome may be suggested.

PMID:
19281806
[PubMed - indexed for MEDLINE]
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