Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Infect Dis. 2009 Feb 15;199(4):565-8. doi: 10.1086/596510.

Ability to replicate in the cytoplasm predicts zoonotic transmission of livestock viruses.

Author information

  • 1Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey, USA. pulliamjuliet@mail.nih.gov

Abstract

Understanding viral factors that promote cross-species transmission is important for evaluating the risk of zoonotic emergence. We constructed a database of viruses of domestic artiodactyls and examined the correlation between traits linked in the literature to cross-species transmission and the ability of viruses to infect humans. Among these traits--genomic material, genome segmentation, and replication without nuclear entry--the last is the strongest predictor of cross-species transmission. This finding highlights nuclear entry as a barrier to transmission and suggests that the ability to complete replication in the cytoplasm may prove to be a useful indicator of the threat of cross-species transmission.

PMID:
19281304
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for HighWire
    Loading ...
    Write to the Help Desk