J Infect Chemother. 2009 Feb;15(1):1-5. Epub 2009 Mar 12.

In vitro antifungal combination effects of micafungin with fluconazole, voriconazole, amphotericin B, and flucytosine against clinical isolates of Candida species.

Nishi I, Sunada A, Toyokawa M, Asari S, Iwatani Y.

Source

Laboratory for Clinical Investigation, Osaka University Hospital, 2-15 Yamadaoka, Suita, Osaka 565-0871, Japan. nishi@hp-lab.med.osaka-u.ac.jp

Erratum in

J Infect Chemother. 2009 Apr;15(2):123-4.

Abstract

Micafungin (MCFG) is an echinocandin antifungal agent that exhibits potent activity against most species of Candida and Aspergillus. We investigated the in vitro antifungal combination effects of MCFG with four other antifungal agents - fluconazole (FLCZ), voriconazole (VRCZ), amphotericin B, and flucytosine - against clinical isolates of 54 Candida spp. by checkerboard analysis. The synergistic antifungal effects of MCFG-FLCZ and MCFG-VRCZ were 11% and 15%, respectively, and the latter displayed a synergistic activity of 63% against Candida glabrata. Antagonism was not observed in any of the combinations tested.

PMID:: 19280292; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Other Literature Sources

See the articles identified as outstanding by F1000's Faculty of 10,000 renowned researchers and clinicians. - F1000

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

In vitro activities of voriconazole (UK-109,496) and four other antifungal agents against 394 clinical isolates of Candida spp. [Antimicrob Agents Chemother. 1...]
In vitro activities of voriconazole (UK-109,496) and four other antifungal agents against 394 clinical isolates of Candida spp.
Marco F, Pfaller MA, Messer S, Jones RN. Antimicrob Agents Chemother. 1998 Jan; 42(1):161-3.
National surveillance of species distribution in blood isolates of Candida species in Japan and their susceptibility to six antifungal agents including voriconazole and micafungin. [J Antimicrob Chemother. 2004]
National surveillance of species distribution in blood isolates of Candida species in Japan and their susceptibility to six antifungal agents including voriconazole and micafungin.
Takakura S, Fujihara N, Saito T, Kudo T, Iinuma Y, Ichiyama S. J Antimicrob Chemother. 2004 Feb; 53(2):283-9. Epub 2003 Dec 19.
[In vitro activity of a new semisynthetic echinocandin, micafungin, against clinical isolates of Candida species isolated in Tenri Hospital]. [Jpn J Antibiot. 2003]
[In vitro activity of a new semisynthetic echinocandin, micafungin, against clinical isolates of Candida species isolated in Tenri Hospital].
Komatsu M, Aihara M, Shimakawa K, Iwasaki M, Nagasaka Y, Fukuda S, Abe N, Matsuo S. Jpn J Antibiot. 2003 Dec; 56(6):705-11.
Review In vitro antifungal activities of anidulafungin and micafungin, licensed agents and the investigational triazole posaconazole as determined by NCCLS methods for 12,052 fungal isolates: review of the literature. [Rev Iberoam Micol. 2003]
Review In vitro antifungal activities of anidulafungin and micafungin, licensed agents and the investigational triazole posaconazole as determined by NCCLS methods for 12,052 fungal isolates: review of the literature.
Espinel-Ingroff A. Rev Iberoam Micol. 2003 Dec; 20(4):121-36.
Review In vitro antifungal activities of voriconazole and reference agents as determined by NCCLS methods: review of the literature. [Mycopathologia. 2001]
Review In vitro antifungal activities of voriconazole and reference agents as determined by NCCLS methods: review of the literature.
Espinel-Ingroff A, Boyle K, Sheehan DJ. Mycopathologia. 2001; 150(3):101-15.

See reviews... See all...

Cited by 1 PubMed Central article

Multilaboratory testing of two-drug combinations of antifungals against Candida albicans, Candida glabrata, and Candida parapsilosis. [Antimicrob Agents Chemother. 2...]
Multilaboratory testing of two-drug combinations of antifungals against Candida albicans, Candida glabrata, and Candida parapsilosis.
Chaturvedi V, Ramani R, Andes D, Diekema DJ, Pfaller MA, Ghannoum MA, Knapp C, Lockhart SR, Ostrosky-Zeichner L, Walsh TJ, et al. Antimicrob Agents Chemother. 2011 Apr; 55(4):1543-8. Epub 2011 Jan 31.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

In vitro antifungal combination effects of micafungin with fluconazole, voricona...
In vitro antifungal combination effects of micafungin with fluconazole, voriconazole, amphotericin B, and flucytosine against clinical isolates of Candida species.
J Infect Chemother. 2009 Feb ;15(1):1-5. Epub 2009 Mar 12 .

PubMed
Intravenous drug users and AIDS: risk behaviors.
Intravenous drug users and AIDS: risk behaviors.
Am J Drug Alcohol Abuse. 1991 Sep ;17(3):337-53.

PubMed
Mid-term follow-up after sleeve gastrectomy as a final approach for morbid obesi...
Mid-term follow-up after sleeve gastrectomy as a final approach for morbid obesity.
Obes Surg. 2009 May ;19(5):544-8. Epub 2009 Mar 12 .

PubMed
Human immunodeficiency disease: how should it affect surgical decision making?
Human immunodeficiency disease: how should it affect surgical decision making?
World J Surg. 2009 May ;33(5):899-909.

PubMed
A comparative trial of psychotherapies for ambulatory cocaine abusers: relapse p...
A comparative trial of psychotherapies for ambulatory cocaine abusers: relapse prevention and interpersonal psychotherapy.
Am J Drug Alcohol Abuse. 1991 Sep ;17(3):229-47.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

In vitro antifungal combination effects of micafungin with fluconazole, voriconazole, amphotericin B, and flucytosine against clinical isolates of Candida species.

Source

Erratum in

Abstract

MeSH Terms, Substances

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Cited by 1 PubMed Central article

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information