South Med J. 2009 Apr;102(4):405-7.

An unusual case of colonic ischemia.

Source

Gastroenterology Service, Walter Reed Army Medical Center, Washington, DC 20307, USA. fouad.moawad@amedd.army.mil

Abstract

Sumatriptan is widely prescribed for the treatment of migraine headaches. Its actions are mediated via agonist action on the vascular 5-hydroxytryptamine 1 receptor which results in vasoconstriction. We report a case of a 46-year-old woman who developed ischemic colitis while taking increasing doses of sumatriptan for a migraine headache. Her only other medication was oral contraceptives. Interestingly, a potential synergistic action between the two medications may exist since estrogen reduces triptan clearance through its action on monamine oxide, an enzyme that metabolizes serotonin. Sumatriptan should be recognized as an important cause of drug-induced colonic ischemia, especially in patients taking estrogen.

Comment in

South Med J. 2009 Apr;102(4):345-6.

PMID:: 19279546; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Case Reports

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Molecular Biology Databases

Sumatriptan - HSDB

Supplemental Content

Save items

Related citations in PubMed

Ischemic colitis related to sumatriptan overuse. [J Am Board Fam Med. 2010]
Ischemic colitis related to sumatriptan overuse.
Hodge JA, Hodge KD. J Am Board Fam Med. 2010 Jan-Feb; 23(1):124-7.
Ischemic colitis and sumatriptan use. [Arch Intern Med. 1998]
Ischemic colitis and sumatriptan use.
Knudsen JF, Friedman B, Chen M, Goldwasser JE. Arch Intern Med. 1998 Sep 28; 158(17):1946-8.
Spontaneous splenic infarction associated with sumatriptan use. [J Headache Pain. 2006]
Spontaneous splenic infarction associated with sumatriptan use.
Arora A, Arora S. J Headache Pain. 2006 Sep; 7(4):214-6. Epub 2006 Jun 15.
Review Ischemic colitis after weight-loss medication. [Can J Gastroenterol. 2003]
Review Ischemic colitis after weight-loss medication.
Comay D, Ramsay J, Irvine EJ. Can J Gastroenterol. 2003 Dec; 17(12):719-21.
Review [Ischemic colitis induced by cocaine. Clinical case]. [Rev Med Chil. 2002]
Review [Ischemic colitis induced by cocaine. Clinical case].
Boza C, Dagnino B, Garrido AM, Llanos O. Rev Med Chil. 2002 Jun; 130(6):667-70.

See reviews... See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.

Recent activity

Clear Turn Off Turn On

An unusual case of colonic ischemia.
An unusual case of colonic ischemia.
South Med J. 2009 Apr ;102(4):405-7.

PubMed
Overdose in infant caused by over-the-counter cough medicine.
Overdose in infant caused by over-the-counter cough medicine.
South Med J. 2009 Apr ;102(4):440-2.

PubMed
Management of osteoporosis among home health and long-term care patients with a ...
Management of osteoporosis among home health and long-term care patients with a prior fracture.
South Med J. 2009 Apr ;102(4):397-404.

PubMed
Rapunzel syndrome-a rare cause of multiple jejunal intussusception.
Rapunzel syndrome-a rare cause of multiple jejunal intussusception.
South Med J. 2009 Apr ;102(4):416-8.

PubMed
Caffeinated and alcoholic beverage intake in relation to ovulatory disorder infe...
Caffeinated and alcoholic beverage intake in relation to ovulatory disorder infertility.
Epidemiology. 2009 May ;20(3):374-81.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: