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J Neuroimmunol. 2009 Apr 30;209(1-2):139-42. doi: 10.1016/j.jneuroim.2009.02.006. Epub 2009 Mar 10.

The trigeminal retrograde transfer pathway in the treatment of neurodegeneration.

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  • 1Department of Children's Dentistry, Stony Brook University, Stony Brook, NY 11794-8700, USA. kyrkanides@gmail.com

Abstract

The trigeminal sensory system was evaluated for the retrograde transfer of gene therapy vectors into the CNS. The feline immunodeficiency viral vector, FIV(HEXB), encoding for the human HEXB gene, was injected intra-articularly in the temporomandibular joint of 12 week-old HexB(-/-) mice displaying clinical and histopathological signs of Sandhoff disease. This treatment regiment reduced GM(2) storage and ameliorated neuroinflammation in the brain of HexB(-/-) mice, as well as attenuated behavioral deficits. In conclusion, retrograde transfer along trigeminal sensory nerves may prove to be a valuable route of gene therapy administration for the treatment of lysosomal storage disorders and other neurodegenerative diseases.

PMID:
19278737
[PubMed - indexed for MEDLINE]
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