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Infect Disord Drug Targets. 2009 Apr;9(2):126-32.

Drug targets in rhinoviral infections.

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  • 1University Hospital Bergmannsheil, Medical Clinic III, Department of Pneumology, Allergology and Sleep Medicine, Ruhr-University Bochum, Germany. gernot.rohde@ruhr-uni-bochum.de

Abstract

Human Rhinoviruses (HRV) are by far the most common respiratory viruses responsible for most cases of the common cold and important pathogens in acute exacerbations of asthma and COPD. The molecular pathogenesis of HRV infection is quite completely understood. However there is still no approved specific treatment against HRV infections. The aim of this article is therefore to give an overview of the principles of rhinovirus infection, the associated therapeutic targets and to review up-to-date virus-specific clinical trials.

PMID:
19275701
[PubMed - indexed for MEDLINE]
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