Laser-induced fluorescence and reflected white light imaging for robot-assisted MIS

IEEE Trans Biomed Eng. 2009 Mar;56(3):889-92. doi: 10.1109/TBME.2008.2006623. Epub 2008 Oct 31.

Abstract

This paper presents an articulated robotic-controlled device to facilitate large-area in vivo tissue imaging and characterization through the integration of miniaturized reflected white light and fluorescence intensity imaging for minimally invasive surgery (MIS). The device is composed of a long, rigid shaft with a robotically controlled distal tip featuring three degrees of in-plane articulation and one degree of rotational freedom. The constraints imposed by the articulated section, coupled with the small footprint available in MIS devices, require a novel optical configuration to ensure effective target illumination and image acquisition. A tunable coherent supercontinuum laser source is used to provide sequential white light and fluorescence illumination through a multimode fiber (200 microm diameter), and the reflected images are transmitted to an image acquisition system using a 10,000 pixel flexible fiber image guide (590 microm diameter). By using controlled joint actuation to trace overlapping trajectories, the device allows effective imaging of a larger field of view than a traditional dual-mode laparoscope. A first-generation prototype of the device and its initial phantom and ex vivo tissue characterization results are described. The results demonstrate the potential of the device to be used as a new platform for in vivo tissue characterization and navigation for MIS.

MeSH terms

  • Equipment Design
  • Fiber Optic Technology
  • Fluorescence
  • Humans
  • Image Enhancement / instrumentation*
  • Lasers*
  • Minimally Invasive Surgical Procedures / instrumentation*
  • Optics and Photonics / instrumentation*
  • Phantoms, Imaging
  • Reproducibility of Results
  • Robotics / instrumentation*