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Nat Neurosci. 2009 Apr;12(4):393-5. doi: 10.1038/nn.2286. Epub 2009 Mar 8.

D2R striatopallidal neurons inhibit both locomotor and drug reward processes.

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  • 1Laboratory of Neurophysiology, Universit√© Libre de Bruxelles, Brussels, Belgium.


The specific functions of dopamine D(2) receptor-positive (D(2)R) striatopallidal neurons remain poorly understood. Using a genetic mouse model, we found that ablation of D(2)R neurons in the entire striatum induced hyperlocomotion, whereas ablation in the ventral striatum increased amphetamine conditioned place preference. Thus D(2)R striatopallidal neurons limit both locomotion and, unexpectedly, drug reinforcement.

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