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Cell Cycle. 2009 Apr 1;8(7):1014-8. Epub 2009 Apr 9.

RAG GTPases in nutrient-mediated TOR signaling pathway.

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  • 1Department of Food Sciences and Nutrition, Catholic University of Daegu, Gyeongsan-si, Gyeongbuk, Repulic of Korea.


Amino acids are key nutrients for protein synthesis and many metabolic processes. There is compelling evidence that amino acids themselves regulate protein synthesis, degradation and cell growth. Mammalian target of rapamycin complex 1 (mTORC1) plays a central role in cellular growth regulation. Amino acids potently activate mTORC1, however, the mechanism of amino acid signaling is largely unknown. Recent studies have identified Rag small GTPases as key components mediating amino acid signals to mTORC1 activation.

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