FEBS Lett. 2009 Jun 5;583(11):1759-65. Epub 2009 Mar 6.

A network medicine approach to human disease.

Source

Institute for Research in Biomedicine and Barcelona Supercomputing Center, c/ Baldiri i Reixac 10-12, 08028 Barcelona, Spain.

Abstract

High-throughput interaction discovery initiatives are providing thousands of novel protein interactions which are unveiling many unexpected links between apparently unrelated biological processes. In particular, analyses of the first draft human interactomes highlight a strong association between protein network connectivity and disease. Indeed, recent exciting studies have exploited the information contained within protein networks to disclose some of the molecular mechanisms underlying complex pathological processes. These findings suggest that both protein-protein interactions and the networks themselves could emerge as a new class of targetable entities, boosting the quest for novel therapeutic strategies.

PMID:: 19269289; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

Proteins

LinkOut - more resources

Full Text Sources

Supplemental Content

Related citations

Review The Cartographers toolbox: building bigger and better human protein interaction networks. [Brief Funct Genomic Proteomic. 2009]
Review The Cartographers toolbox: building bigger and better human protein interaction networks.
Sanderson CM. Brief Funct Genomic Proteomic. 2009 Jan; 8(1):1-11. Epub 2009 Mar 12.
Interaction between intrinsically disordered proteins frequently occurs in a human protein-protein interaction network. [J Mol Biol. 2009]
Interaction between intrinsically disordered proteins frequently occurs in a human protein-protein interaction network.
Shimizu K, Toh H. J Mol Biol. 2009 Oct 9; 392(5):1253-65. Epub 2009 Aug 3.
Building disease-specific drug-protein connectivity maps from molecular interaction networks and PubMed abstracts. [PLoS Comput Biol. 2009]
Building disease-specific drug-protein connectivity maps from molecular interaction networks and PubMed abstracts.
Li J, Zhu X, Chen JY. PLoS Comput Biol. 2009 Jul; 5(7):e1000450. Epub 2009 Jul 31.
Identifying disease-specific genes based on their topological significance in protein networks. [BMC Syst Biol. 2009]
Identifying disease-specific genes based on their topological significance in protein networks.
Dezso Z, Nikolsky Y, Nikolskaya T, Miller J, Cherba D, Webb C, Bugrim A. BMC Syst Biol. 2009 Mar 23; 3:36. Epub 2009 Mar 23.
Review Evolution of biomolecular networks: lessons from metabolic and protein interactions. [Nat Rev Mol Cell Biol. 2009]
Review Evolution of biomolecular networks: lessons from metabolic and protein interactions.
Yamada T, Bork P. Nat Rev Mol Cell Biol. 2009 Nov; 10(11):791-803.

See reviews... See all...

Cited by 8 PubMed Central articles

Review Network medicine: a network-based approach to human disease. [Nat Rev Genet. 2011]
Review Network medicine: a network-based approach to human disease.
Barabási AL, Gulbahce N, Loscalzo J. Nat Rev Genet. 2011 Jan; 12(1):56-68.
Interactome mapping suggests new mechanistic details underlying Alzheimer's disease. [Genome Res. 2011]
Interactome mapping suggests new mechanistic details underlying Alzheimer's disease.
Soler-López M, Zanzoni A, Lluís R, Stelzl U, Aloy P. Genome Res. 2011 Mar; 21(3):364-76. Epub 2010 Dec 16.
Revealing the molecular relationship between type 2 diabetes and the metabolic changes induced by a very-low-carbohydrate low-fat ketogenic diet. [Nutr Metab (Lond). 2010]
Revealing the molecular relationship between type 2 diabetes and the metabolic changes induced by a very-low-carbohydrate low-fat ketogenic diet.
Farrés J, Pujol A, Coma M, Ruiz JL, Naval J, Mas JM, Molins A, Fondevila J, Aloy P. Nutr Metab (Lond). 2010 Dec 9; 7:88. Epub 2010 Dec 9.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

A network medicine approach to human disease.
A network medicine approach to human disease.
FEBS Lett. 2009 Jun 5 ;583(11):1759-65. Epub 2009 Mar 6 .

PubMed
Contextual specificity in peptide-mediated protein interactions.
Contextual specificity in peptide-mediated protein interactions.
PLoS One. 2008 Jul 2 ;3(7):e2524.

PubMed
Approved drug mimics of short peptide ligands from protein interaction motifs.
Approved drug mimics of short peptide ligands from protein interaction motifs.
J Chem Inf Model. 2008 Oct ;48(10):1943-8. Epub 2008 Oct 1 .

PubMed
Splitting statistical potentials into meaningful scoring functions: testing the ...
Splitting statistical potentials into meaningful scoring functions: testing the prediction of near-native structures from decoy conformations.
BMC Struct Biol. 2009 Nov 16 ;9:71.

PubMed
Novel peptide-mediated interactions derived from high-resolution 3-dimensional s...
Novel peptide-mediated interactions derived from high-resolution 3-dimensional structures.
PLoS Comput Biol. 2010 May 20 ;6(5):e1000789.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to: