[Schizophrenia and circadian rhythms]

Encephale. 2009 Jan:35 Suppl 2:S80-3. doi: 10.1016/S0013-7006(09)75540-X.
[Article in French]

Abstract

Circadian rhythms have not been widely studied in schizophrenic patients, probably for methodological feasibility reasons. The available findings relate to the awake/asleep cycle and are not particularly up to date. Clinically' the reduction in overall sleep time and sleep fragmentation are usual but relatively non-specific findings in decompensated psychotic episodes. Although H Ey's hypothesis of intermediate sleep by has not been followed up, EEG recordings support moderate abnormalities linked to certain times of progression such as a possible increase in MOR density or reduction in REM latency in delusional phases. The reduction in SLP is thought to be more a marker of the schizophrenic state as an illness. A possible action of some antipsychotics on sleep fragmentation would give them resynchronising activity, which remains to be confirmed.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Acute Disease
  • Antipsychotic Agents / adverse effects
  • Antipsychotic Agents / therapeutic use
  • Circadian Rhythm / drug effects
  • Circadian Rhythm / physiology*
  • Humans
  • Melatonin / blood
  • Recurrence
  • Schizophrenia / drug therapy
  • Schizophrenia / physiopathology*
  • Schizophrenic Psychology*
  • Sleep Deprivation / physiopathology
  • Sleep Deprivation / psychology
  • Sleep, REM / drug effects
  • Sleep, REM / physiology

Substances

  • Antipsychotic Agents
  • Melatonin