Ontogenesis of circadian rhythms in human beings, the history of the development of synchronisation of the daily rhythm describes the deployment of an adaptive capacity providing vital biological linkage to the environment. Methods for dating the stages in this temporal organisation have advanced and the genetics approach to the circadian cycle is dominated by studies of the maturation of the awake-asleep cycle. Disease involves the functional regression to one of the different stages of genesis or alternatively will involve a pathological lesion. Circadian dysfunction is characterised by loss of amplitude and multi-day fragmentation, correction of which requires control of multi-day pressure and within-day stabilisation.