Cell Stem Cell. 2009 Mar 6;4(3):187-8.

Key endothelial signals required for hematopoietic recovery.

Source

Wilmot Cancer Center and Endocrine Division, University of Rochester School of Medicine, 601 Elmwood Avenue, Box 693, Rochester, NY 14642, USA.

Abstract

In this issue of Cell Stem Cell, Hooper et al. (2009) use a combination of immunohistochemistry and flow cytometry to characterize the bone marrow vasculature both before and after injury. The authors demonstrate that recovery of normal hematopoiesis after myelosuppressive insult is dependent upon endothelial VEGFR2.

Comment on

Cell Stem Cell. 2009 Mar 6;4(3):263-74.

PMID:: 19265650; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

Comment

MeSH Terms

Substances

Vascular Endothelial Growth Factor Receptor-2

Grant Support

R01 DK076876-01A2/DK/NIDDK NIH HHS/United States

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Engraftment and reconstitution of hematopoiesis is dependent on VEGFR2-mediated regeneration of sinusoidal endothelial cells. [Cell Stem Cell. 2009]
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