Science. 2009 Mar 6;323(5919):1304-7. doi: 10.1126/science.1165706.

The challenge of finding a cure for HIV infection.

Richman DD, Margolis DM, Delaney M, Greene WC, Hazuda D, Pomerantz RJ.

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San Diego VA Healthcare System and University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0679, USA. drichman@ucsd.edu

Abstract

Although combination therapy for HIV infection represents a triumph for modern medicine, chronic suppressive therapy is required to contain persistent infection in reservoirs such as latently infected CD4+ lymphocytes and cells of the macrophage-monocyte lineage. Despite its success, chronic suppressive therapy is limited by its cost, the requirement of lifelong adherence, and the unknown effects of long-term treatment. This review discusses our current understanding of suppressive antiretroviral therapy, the latent viral reservoir, and the needs for and challenges of attacking this reservoir to achieve a cure.

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A step ahead on the HIV collaboratory. [Science. 2009]
A step ahead on the HIV collaboratory.Murphy RL, Autran B, Katlama C, Brucker G, Debre P, Calvez V, Clotet B, Clumeck N, Costagliola D, Deeks SG, et al. Science. 2009 Jun 5; 324(5932):1264-5.

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The challenge of finding a cure for HIV infection.
The challenge of finding a cure for HIV infection.
Science. 2009 Mar 6 ;323(5919):1304-7. doi: 10.1126/science.1165706.

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