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Head Neck. 2009 Jun;31(6):759-64. doi: 10.1002/hed.21027.

Higher laryngeal preservation rate after CO2 laser surgery compared with radiotherapy in T1a glottic laryngeal carcinoma.

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  • 1Department of Otorhinolaryngology-Head and Neck surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.



Clinical outcome of endoscopic CO(2) laser surgery and radiotherapy in early-stage glottic laryngeal carcinoma is difficult to compare because of differences in treatment selection and patient groups. Therefore, we compared local control, overall survival, and laryngeal preservation in a homogenous group of patients with T1a glottic carcinoma with normal/diminished mucosal wave treated with either CO(2) laser surgery or radiotherapy.


Retrospective survival analysis was performed on 100 patients with T1a glottic carcinoma treated with CO(2) laser surgery (n = 49) or radiotherapy (n = 51), diagnosed at the University Medical Center Groningen between 1990 and 2004.


No significant differences in local control and overall survival were found. Ultimate 5-year laryngeal preservation was significantly better in the CO(2) laser surgery group (95% vs 77%, p = .043).


Patients with T1a glottic carcinoma with normal/diminished mucosal wave treated with CO(2) laser surgery had a significantly better laryngeal preservation rate than patients treated with radiotherapy.

(c) 2009 Wiley Periodicals, Inc.

[PubMed - indexed for MEDLINE]
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