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Opt Express. 2009 Mar 2;17(5):3884-902.

Transcranial optical monitoring of cerebrovascular hemodynamics in acute stroke patients.

Author information

  • 1Departments of Radiology, University of Pennsylvania, PA, USA. durduran@alumni.upenn.edu

Abstract

"Diffuse correlation spectroscopy" (DCS) is a technology for non-invasive transcranial measurement of cerebral blood flow (CBF) that can be hybridized with "near-infrared spectroscopy" (NIRS). Taken together these methods hold potential for monitoring hemodynamics in stroke patients. We explore the utility of DCS and NIRS to measure effects of head-of-bed (HOB) positioning at 30 degrees , 15 degrees , 0 degrees , -5 degrees and 0 degrees angles in patients with acute ischemic stroke affecting frontal cortex and in controls. HOB positioning significantly altered CBF, oxy-hemoglobin (HbO(2)) and total-hemoglobin (THC) concentrations. Moreover, the presence of an ipsilateral infarct was a significant effect for all parameters. Results are consistent with the notion of impaired CBF autoregulation in the infarcted hemisphere.

PMID:
19259230
[PubMed - indexed for MEDLINE]
PMCID:
PMC2724658
Free PMC Article

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