Opt Express. 2009 Mar 2;17(5):3884-902.

Transcranial optical monitoring of cerebrovascular hemodynamics in acute stroke patients.

Durduran T, Zhou C, Edlow BL, Yu G, Choe R, Kim MN, Cucchiara BL, Putt ME, Shah Q, Kasner SE, Greenberg JH, Yodh AG, Detre JA.

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Departments of Radiology, University of Pennsylvania, PA, USA. durduran@alumni.upenn.edu

Abstract

"Diffuse correlation spectroscopy" (DCS) is a technology for non-invasive transcranial measurement of cerebral blood flow (CBF) that can be hybridized with "near-infrared spectroscopy" (NIRS). Taken together these methods hold potential for monitoring hemodynamics in stroke patients. We explore the utility of DCS and NIRS to measure effects of head-of-bed (HOB) positioning at 30 degrees , 15 degrees , 0 degrees , -5 degrees and 0 degrees angles in patients with acute ischemic stroke affecting frontal cortex and in controls. HOB positioning significantly altered CBF, oxy-hemoglobin (HbO(2)) and total-hemoglobin (THC) concentrations. Moreover, the presence of an ipsilateral infarct was a significant effect for all parameters. Results are consistent with the notion of impaired CBF autoregulation in the infarcted hemisphere.

PMID:: 19259230; [PubMed - indexed for MEDLINE]
PMCID:: PMC2724658

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