Mol Hum Reprod. 2009 May;15(5):269-70. Epub 2009 Mar 3.

OCT4B1 isoform: the novel OCT4 alternative spliced variant as a putative marker of stemness.

Papamichos SI, Kotoula V, Tarlatzis BC, Agorastos T, Papazisis K, Lambropoulos AF.

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First Department of Obstetrics and Gynaecology, General Regional Hospital Papageorgiou, Aristotle University, Thessaloniki, Greece. spmedauth@yahoo.gr

Abstract

A novel OCT4 alternative spliced variant (OCT 4B1) is deduced to be the isoform present in 59 hESC lines characterised by the International Stem Cell Initiative (ISCI) rather than OCT4A as previously assumed. The new variant may be a more reliable marker of stemness than OCT4A and studies are needed to test this.

PMID:: 19258399; [PubMed - indexed for MEDLINE]

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