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J Am Chem Soc. 2009 Mar 25;131(11):3822-3. doi: 10.1021/ja809236a.

Light-regulated activation of cellular signaling by gold nanoparticles that capture and release amines.

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  • 1World Premier International Research Center Initiative, International Center for Materials Nanoarchitectonics, National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba, Ibaraki 305-0044, Japan. nakanishi.jun@nims.go.jp


A photoresponsive nanocarrier for amines based on gold nanoparticles (GNPs) having a photocleavable succinimidyl ester has been developed. It offers a useful platform for the synthesis of caged compounds. Using the GNPs, we have developed caged histamine for the first time and applied it to evoke intracellular signaling by controlled near-UV irradiation. The present work will allow for new possibilities in studies of inter- and intracellular signaling networks.

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