Targets for dioxin: genes for plasminogen activato...[Science. 1991]

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1: Science. 1991 Oct 18;254(5030):415-8. Links

Targets for dioxin: genes for plasminogen activator inhibitor-2 and interleukin-1 beta.

Sutter TR, Guzman K, Dold KM, Greenlee WF.

Chemical Industry Institute of Toxicology, Research Triangle Park, NC 27709.

Dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin, TCDD), a widespread environmental contaminant, may elicit its effects by altering gene expression in susceptible cells. Five TCDD-responsive complementary DNA clones were isolated from a human keratinocyte cell line. One of these clones encodes plasminogen activator inhibitor-2, a factor that influences growth and differentiation by regulating proteolysis of the extracellular matrix. Another encodes the cytokine interleukin-1 beta. Thus, TCDD alters the expression of growth regulatory genes and has effects similar to those of other tumor-promoting agents that affect both inflammation and differentiation.

PMID: 1925598 [PubMed - indexed for MEDLINE]

Expression of dioxin-responsive genes in human endometrial cells in culture.
Biochem Biophys Res Commun. 1999 Apr 13; 257(2):259-63.

[Biochem Biophys Res Commun. 1999]
Regulation of gene expression and acceleration of differentiation in human keratinocytes by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Toxicol Appl Pharmacol. 1994 Aug; 127(2):199-208.

[Toxicol Appl Pharmacol. 1994]
Post-transcriptional stabilization of urokinase plasminogen activator mRNA by 2,3,7,8-tetrachlorodibenzo-p-dioxin in a human keratinocyte cell line.
Toxicol Appl Pharmacol. 1995 Jul; 133(1):34-42.

[Toxicol Appl Pharmacol. 1995]
Gene expression and cell proliferation in rat liver after 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure.
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[Cancer Res. 1993]
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[J Cell Biochem. 1987]
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Cited by 22 PubMed Central articles

EGF receptor signaling blocks aryl hydrocarbon receptor-mediated transcription and cell differentiation in human epidermal keratinocytes.
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