Cell Metab. 2009 Mar;9(3):215-6.

A sweet path to insulin resistance through PGC-1beta.

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Life Sciences Institute and Department of Cell & Developmental Biology, University of Michigan Medical Center, Ann Arbor, MI 48109, USA.

Abstract

Fructose is a highly lipogenic dietary nutrient that has been implicated in the pathogenesis of hyperlipidemia and insulin resistance. In this issue, Nagai et al. (2009) provide in vivo evidence that pinpoints transcriptional coactivator PGC-1beta as a key factor in mediating the metabolic response to fructose intake.

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Cell Metab. 2009 Mar;9(3):252-64.

PMID:: 19254566; [PubMed - indexed for MEDLINE]

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The role of peroxisome proliferator-activated receptor gamma coactivator-1 beta in the pathogenesis of fructose-induced insulin resistance. [Cell Metab. 2009]
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Cited by 2 PubMed Central articles

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