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    Retrovirology. 2009 Mar 2;6:22.

    Inhibition of HIV-1 gene expression by Sam68 Delta C: multiple targets but a common mechanism?

    Cochrane A.

    Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada. alan.cochrane@utoronto.ca

    Two recent publications have explored the mechanisms by which a mutant of the host protein Sam68 blocks HIV-1 structural protein synthesis and expands its activity to encompass Nef. Although the two studies propose different mechanisms for the responses observed, it is possible that a common activity is responsible. Understanding how this Sam68 mutant discriminates among the multiple viral mRNAs promises to reveal unique properties of HIV-1 RNA metabolism.

    PMID: 19254361 [PubMed - indexed for MEDLINE]

    PMCID: PMC2651844

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