Tissue Antigens. 2009 Mar;73(3):262-9.

HLA class I allele and haplotype diversity in Ugandans supports the presence of a major east African genetic cluster.

Kijak GH, Walsh AM, Koehler RN, Moqueet N, Eller LA, Eller M, Currier JR, Wang Z, Wabwire-Mangen F, Kibuuka HN, Michael NL, Robb ML, McCutchan FE.

Source

Division of Retrovirology, US Military HIV Research Program/Henry M. Jackson Foundation, Rockville, MD 20850, USA. gkijak@hivresearch.org

Abstract

The objective of this study was to characterize the class I human leukocyte antigen (HLA) genetic composition of the Ugandan population to better define its relationship with other African groups. Samples from 175 individuals from Kampala (Uganda) were subjected to class I HLA-A, -B, and -C sequence-based typing. The high concordance between the major alleles and haplotypes found in the current and Kenyan populations and interpopulation genetic distance analysis strongly supported the presence of an East African cluster that contained the current Ugandan population along with Kenyan Luo and Nandi populations. The congruence of major alleles in different populations would permit consideration of East Africa as an integrated setting when designing and evaluating much needed malaria, tuberculosis, and AIDS vaccines.

PMID:: 19254258; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Histocompatibility Antigens Class I

Grant Support

2 Y1-AI-2642-11/AI/NIAID NIH HHS/United States

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Medical

Malaria and HIV - HIV InSite

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