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    Intern Med. 2009;48(5):373-5. Epub 2009 Mar 2.

    Chronic inflammatory demyelinating polyneuropathy after treatment with interferon-alpha.

    Hirotani M, Nakano H, Ura S, Yoshida K, Niino M, Yabe I, Sasaki H.

    Source

    Department of Neurology, Hokkaido University Graduate School of Medicine, Sapporo. hirotani@med.hokudai.ac.jp

    Abstract

    Interferon-alpha (IFN-alpha), though widely used for the treatment of chronic viral hepatitis, may be associated with the occurrence of autoimmune disorders. In this case report, a patient with chronic hepatitis C virus infection had chronic inflammatory demyelinating polyneuropathy (CIDP) after the initiation of IFN-alpha therapy. The neurological symptoms of this patient continued to progress even though the treatment with IFN-alpha had been withdrawn; the symptoms improved dramatically following treatment with intravenous immunoglobulin. This case may therefore provide an important clue to understand the immune mechanism of CIDP and IFN-alpha.

    PMID:
    19252365
    [PubMed - indexed for MEDLINE]
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