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Intern Med. 2009;48(5):347-52. Epub 2009 Mar 2.

Takotsubo cardiomyopathy during acute adrenal crisis due to isolated adrenocorticotropin deficiency.

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  • 1The Second Department of Internal Medicine, Kansai Medical University, Osaka. ukitac@hirakata.kmu.ac.jp


We report a 69-year-old woman who had isolated adrenocorticotropic hormone (ACTH) deficiency. Subsequently, she had Takotsubo cardiomyopathy during acute adrenal crisis. Replacement therapy with hydrocortisone sufficiently improved her cardiomyopathy. We conclude that her myocardial dysfunction was closely related to adrenal insufficiency and suggest that in certain circumstances, adrenal crisis may cause Takotsubo cardiomyopathy.

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