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Diabetes Care. 2009 Jun;32(6):1081-6. doi: 10.2337/dc08-1895. Epub 2009 Feb 27.

Objectively measured moderate- and vigorous-intensity physical activity but not sedentary time predicts insulin resistance in high-risk individuals.

Author information

  • 1Medical Research Council, Epidemiology Unit, Cambridge, UK. ulf.ekelund@mrc-epid.cam.ac.uk

Abstract

OBJECTIVE:

Low levels of physical activity appear to be associated with insulin resistance. However, the detailed associations of these complex relationships remain elusive. We examined the prospective associations between self-reported TV viewing time, objectively measured time spent sedentary, at light-intensity activity, and at moderate- and vigorous-intensity physical activity (MVPA) with insulin resistance.

RESEARCH DESIGN AND METHODS:

In 192 individuals (81 men and 111 women) with a family history of type 2 diabetes, we measured physical activity and anthropometric and metabolic variables at baseline and after 1 year of follow-up in the ProActive UK trial. Physical activity was measured objectively by accelerometry. Insulin resistance was expressed as fasting insulin and the homeostasis model assessment score (HOMA-IR).

RESULTS:

Baseline MVPA was a significant predictor of fasting insulin at follow-up (beta = -0.004 [95% CI -0.007 to -0.0001], P = 0.022), and the association approached significance for HOMA-IR (beta = -0.003 [-0.007 to 0.000002], P = 0.052), independent of time spent sedentary, at light-intensity activity, sex, age, smoking status, waist circumference, and self-reported TV viewing. Time spent sedentary and at light-intensity activity were not significantly associated with insulin resistance. The change in MVPA between baseline and follow-up was inversely related to fasting insulin (beta = -0.003 [-0.007 to -0.0003], P = 0.032) and the HOMA-IR score (beta = -0.004 [-0.008 to -0.001], P = 0.015) at follow-up, after adjustment for baseline phenotype in addition to the same confounders as above.

CONCLUSIONS:

These results highlight the importance of promoting moderate-intensity activity such as brisk walking for improving insulin sensitivity and possibly other metabolic risk factors to prevent type 2 diabetes.

PMID:
19252168
[PubMed - indexed for MEDLINE]
PMCID:
PMC2681043
Free PMC Article
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