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Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4085-9. doi: 10.1073/pnas.0813019106. Epub 2009 Feb 26.

Picomolar sensitivity MRI and photoacoustic imaging of cobalt nanoparticles.

Author information

  • 1Department of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095, USA. bouchard@chem.ucla.edu

Abstract

Multimodality imaging based on complementary detection principles has broad clinical applications and promises to improve the accuracy of medical diagnosis. This means that a tracer particle advantageously incorporates multiple functionalities into a single delivery vehicle. In the present work, we explore a unique combination of MRI and photoacoustic tomography (PAT) to detect picomolar concentrations of nanoparticles. The nanoconstruct consists of ferromagnetic (Co) particles coated with gold (Au) for biocompatibility and a unique shape that enables optical absorption over a broad range of frequencies. The end result is a dual-modality probe useful for the detection of trace amounts of nanoparticles in biological tissues, in which MRI provides volume detection, whereas PAT performs edge detection.

PMID:
19251659
[PubMed - indexed for MEDLINE]
PMCID:
PMC2657430
Free PMC Article
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