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Am J Surg. 2009 Jul;198(1):105-9. doi: 10.1016/j.amjsurg.2008.08.018. Epub 2009 Feb 27.

Parenteral nutrition maintains pulmonary IgA antibody transport capacity, but not active transport, following injury.

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  • 1Department of Surgery, University of Wisconsin-Madison, College of Medicine, Public Health, Madison, WI, USA.



Parenteral nutrition (PN) increases post-trauma pneumonia versus enteral feeding. PN impairs murine immunoglobulin A (IgA) airway defenses and abrogates a normal IgA increase following injury. This work investigates the effect of type/route of nutrition on lung IgA and its transport protein, polymeric immunoglobulin receptor (pIgR), after injury.


Catheterized mice were randomized to Chow or PN for 5 days and sacrificed without injury (Chow: n = 12; PN n = 11), or 8 hours after laparotomy + neck incisions (Chow-injury: n = 11, PN-injury: n = 13). Bronchoalveolar lavage (BAL) and lung IgA levels were analyzed by enzyme-linked immunosorbent assay (ELISA) and lung pIgR by Western blot.


BAL IgA levels increased in Chow-injury versus PN-injury (P <.01) with no differences in pIgR. PN-injury tissue IgA levels decreased versus Chow (P <.01), Chow-injury (P <.01), and PN (P <.05).


PN impairs the airway IgA response to injury but not due to impaired IgA transport capacity/pIgR level.

[PubMed - indexed for MEDLINE]
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