Cell Signal. 2009 Aug;21(8):1245-54. Epub 2009 Feb 26.

PTH and PTHrP signaling in osteoblasts.

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Division Endocrinology, Department Internal Medicine, Wayne State University School of Medicine, 421 East Canfield Avenue, Detroit, Michigan 48201, USA. ndatta@med.wayne.edu

Abstract

The striking clinical benefit of PTH in osteoporosis began a new era of skeletal anabolic agents. Several studies have been performed, new studies are emerging out and yet controversies remain on PTH anabolic action in bone. This review focuses on the molecular aspects of PTH and PTHrP signaling in light of old players and recent advances in understanding the control of osteoblast proliferation, differentiation and function.

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PMCID:: PMC2723940

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PTH and PTHrP signaling in osteoblasts.

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