DNA Repair (Amst). 2009 Apr 5;8(4):525-35. Epub 2009 Feb 26.

Structural aspects of multi-domain RING/Ubox E3 ligases in DNA repair.

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Division of Biochemistry, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

Abstract

Ubiquitin conjugation plays critical roles in virtually all DNA repair pathways. This review provides an overview of the known multi-domain RING/Ubox E3 ligases and their domain structures. An analysis of known RING/Ubox X-ray and NMR structures leads to a discussion of the effects of dimerization. Structural and mechanistic data relating to the E3 ligase preferences for E2 interaction and chain-type specificity are reviewed and the role of the E3 ligases in regulation of the repair pathways is discussed.

PMID:: 19249250; [PubMed - indexed for MEDLINE]

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