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Kidney Int. 2009 Mar;75(6):578-80. doi: 10.1038/ki.2008.688.

Creatinine and cystatin C: what are the values?

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  • VA Pittsburgh Healthcare System, Pittsburgh, Pennsylvania 15240, USA. Linda.Fried@va.gov


Recent studies indicate that serum cystatin C is a better marker of glomerular filtration rate (GFR) and is a stronger predictor of cardiovascular disease and mortality than serum creatinine. Before cystatin C can gain wide acceptance, information about factors that affect generation, elimination, and analysis is needed. Stevens et al. analyze non-GFR-related factors associated with cystatin C and creatinine levels. The results will be useful in interpreting cystatin C levels in research and clinical practice.

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