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Curr Opin Microbiol. 2009 Apr;12(2):152-60. doi: 10.1016/j.mib.2009.01.010. Epub 2009 Feb 24.

Single domain response regulators: molecular switches with emerging roles in cell organization and dynamics.

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  • 1Biozentrum, University of Basel, Switzerland.


Single domain response regulators (SD-RRs) are signaling components of two-component phosphorylation pathways that harbor a phosphoryl receiver domain but lack a dedicated output domain. The Escherichia coli protein CheY, the paradigm member of this family, regulates chemotaxis by relaying information between chemoreceptors and the flagellar motor switch. New data provide a more complex picture of CheY-mediated motility control in several bacteria and suggest diverging mechanisms in control of cellular motors. Moreover, advances have been made in understanding cellular functions of SD-RRs beyond chemotaxis. We review recent reports indicating that SD-RRs constitute a family of versatile molecular switches that contribute to cellular organization and dynamics as spatial organizer and/or as allosteric regulators of histidine protein kinases.

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