Symposium on 'The challenge of translating nutrition research into public health nutrition'. Session 3: Joint Nutrition Society and Irish Nutrition and Dietetic Institute Symposium on 'Nutrition and autoimmune disease'. Recent advances in genetic understanding of coeliac disease

Proc Nutr Soc. 2009 May;68(2):122-6. doi: 10.1017/S0029665109001074. Epub 2009 Feb 26.

Abstract

Over the past 20 years major advances have been made in the diagnosis and understanding of pathogenic mechanisms relating to coeliac disease. Recently-identified genetic markers support the immunological-inflammatory nature of the disease. It is hoped that these newly-identified genes will assist further dissection of the inflammatory pathways in coeliac disease and give insight into why certain individuals develop intolerance to dietary gluten.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Autoimmune Diseases / genetics*
  • Biopsy
  • Celiac Disease / epidemiology
  • Celiac Disease / genetics*
  • Celiac Disease / immunology
  • Dietetics*
  • Gliadin / immunology
  • Glutens / immunology
  • Histocompatibility Antigens Class II / genetics
  • Humans
  • Intestines / pathology
  • Ireland / epidemiology
  • Nutritional Physiological Phenomena*
  • Societies, Medical

Substances

  • Histocompatibility Antigens Class II
  • Glutens
  • Gliadin