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Chromosoma. 2009 Jun;118(3):279-90. doi: 10.1007/s00412-009-0206-8. Epub 2009 Feb 26.

Monoallelic gene expression in mammals.

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  • 1Siberian Department, Institute of Cytology and Genetics, Russian Academy of Sciences, Novosibirsk, Russia.

Abstract

Three systems of monoallelic gene expression in mammals are known, namely, X-chromosome inactivation, imprinting, and allelic exclusion. In all three systems, monoallelic expression is regulated epigenetically and is frequently directed by long non-coding RNAs (ncRNAs). This review briefs all three systems of monoallelic gene expression in mammals focusing on chromatin modifications, spatial chromosome organization in the nucleus, and the functioning of ncRNAs.

PMID:
19242715
[PubMed - indexed for MEDLINE]
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