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Int Rev Immunol. 2009;28(1):69-92. doi: 10.1080/08830180802593540.

Neutralizing anti-influenza virus monoclonal antibodies: therapeutics and tools for discovery.

Author information

  • 1Department of Microbiology, Mount Sinai School of Medicine, New York, New York, USA. osvaldo.martinez@mssm.edu

Abstract

The human antibody response to influenza virus infection plays a protective role against re-infection, yet little molecular detail is available regarding how human antibodies, when characterized at the monoclonal level, neutralize this important human pathogen. Recent studies, using a diverse array of strategies, have isolated and characterized human anti-virus neutralizing antibodies and shed light not only on the specificity and origin of these antibodies but on their potential for therapeutic use against influenza virus infection.

PMID:
19241254
[PubMed - indexed for MEDLINE]
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