Format

Send to

Choose Destination
See comment in PubMed Commons below
Cell. 2009 Feb 20;136(4):731-45. doi: 10.1016/j.cell.2009.01.042.

Regulation of translation initiation in eukaryotes: mechanisms and biological targets.

Author information

  • 1Department of Biochemistry and Goodman Cancer Centre, McGill University, Montreal, Quebec, H3G 1Y6, Canada. nahum.sonenberg@mcgill.ca

Abstract

Translational control in eukaryotic cells is critical for gene regulation during nutrient deprivation and stress, development and differentiation, nervous system function, aging, and disease. We describe recent advances in our understanding of the molecular structures and biochemical functions of the translation initiation machinery and summarize key strategies that mediate general or gene-specific translational control, particularly in mammalian systems.

[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk