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Cell. 2009 Feb 20;136(4):719-30. doi: 10.1016/j.cell.2009.01.044.

mRNA localization: gene expression in the spatial dimension.

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  • 1Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095-1737, USA. kcmartin@mednet.ucla.edu

Abstract

The localization of mRNAs to subcellular compartments provides a mechanism for regulating gene expression with exquisite temporal and spatial control. Recent studies suggest that a large fraction of mRNAs localize to distinct cytoplasmic domains. In this Review, we focus on cis-acting RNA localization elements, RNA-binding proteins, and the assembly of mRNAs into granules that are transported by molecular motors along cytoskeletal elements to their final destination in the cell.

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