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Pharmacotherapy. 1991;11(4):340-3.

Buspirone in the treatment of posttraumatic stress disorder.

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  • 1Department of Clinical Pharmacy, University of Tennessee, Memphis.


Three patients with a DSM-III-R diagnosis of posttraumatic stress disorder were successfully treated with buspirone in final maximum dosages ranging from 35-60 mg daily. The onset of clinical efficacy ranged from 5-29 days. Symptoms that improved included anxiety, insomnia, flashbacks, and depressed mood. Patients experienced no side effects. Serotonin partial agonist effects are a possible mechanism underlying buspirone's efficacy.

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