Nat Rev Cancer. 2009 Mar;9(3):153-66.

Cell cycle, CDKs and cancer: a changing paradigm.

Source

Cell Division and Cancer Group, Molecular Oncology Programme, Centro Nacional de Investigaciones Oncológicas (CNIO), 28029 Madrid, Spain.

Abstract

Tumour-associated cell cycle defects are often mediated by alterations in cyclin-dependent kinase (CDK) activity. Misregulated CDKs induce unscheduled proliferation as well as genomic and chromosomal instability. According to current models, mammalian CDKs are essential for driving each cell cycle phase, so therapeutic strategies that block CDK activity are unlikely to selectively target tumour cells. However, recent genetic evidence has revealed that, whereas CDK1 is required for the cell cycle, interphase CDKs are only essential for proliferation of specialized cells. Emerging evidence suggests that tumour cells may also require specific interphase CDKs for proliferation. Thus, selective CDK inhibition may provide therapeutic benefit against certain human neoplasias.

PMID:: 19238148; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances, Secondary Source ID

LinkOut - more resources

Full Text Sources

Medical

Supplemental Content

Save items

Related citations in PubMed

Review Cyclins and CDKS in development and cancer: lessons from genetically modified mice. [Front Biosci. 2006]
Review Cyclins and CDKS in development and cancer: lessons from genetically modified mice.
Santamaria D, Ortega S. Front Biosci. 2006 Jan 1; 11:1164-88. Epub 2006 Jan 1.
Revisiting the "Cdk-centric" view of the mammalian cell cycle. [Cell Cycle. 2005]
Revisiting the "Cdk-centric" view of the mammalian cell cycle.
Malumbres M. Cell Cycle. 2005 Feb; 4(2):206-10. Epub 2005 Feb 3.
Review Cyclins and related kinases in cancer cells. [J BUON. 2007]
Review Cyclins and related kinases in cancer cells.
Malumbres M. J BUON. 2007 Sep; 12 Suppl 1:S45-52.
Review Current concepts in neuro-oncology: the cell cycle--a review. [Neurosurgery. 1997]
Review Current concepts in neuro-oncology: the cell cycle--a review.
Dirks PB, Rutka JT. Neurosurgery. 1997 May; 40(5):1000-13; discussion 1013-5.
Review Dual action of the inhibitors of cyclin-dependent kinases: targeting of the cell-cycle progression and activation of wild-type p53 protein. [Expert Opin Investig Drugs. 2006]
Review Dual action of the inhibitors of cyclin-dependent kinases: targeting of the cell-cycle progression and activation of wild-type p53 protein.
Wesierska-Gadek J, Schmid G. Expert Opin Investig Drugs. 2006 Jan; 15(1):23-38.

See reviews... See all...

Cited by over 100 PubMed Central articles

Characterization of cyclin e expression in multiple myeloma and its functional role in seliciclib-induced apoptotic cell death. [PLoS One. 2012]
Characterization of cyclin e expression in multiple myeloma and its functional role in seliciclib-induced apoptotic cell death.
Josefsberg Ben-Yehoshua L, Beider K, Shimoni A, Ostrovsky O, Samookh M, Peled A, Nagler A. PLoS One. 2012; 7(4):e33856. Epub 2012 Apr 25.
Cyclin K goes with Cdk12 and Cdk13. [Cell Div. 2012]
Cyclin K goes with Cdk12 and Cdk13.
Kohoutek J, Blazek D. Cell Div. 2012 Apr 18; 7:12. Epub 2012 Apr 18.
Dual-Specificity Phosphatase CDC25A/B Inhibitor Identified from a Focused Library with Nonelectrophilic Core Structure. [ACS Med Chem Lett. 2012]
Dual-Specificity Phosphatase CDC25A/B Inhibitor Identified from a Focused Library with Nonelectrophilic Core Structure.
Tsuchiya A, Hirai G, Koyama Y, Oonuma K, Otani Y, Osada H, Sodeoka M. ACS Med Chem Lett. 2012 Apr 12; 3(4):294-298. Epub 2012 Feb 15.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Gene
Gene records that cite the current articles. Citations in Gene are added manually by NCBI or imported from outside public resources.
HomoloGene
HomoloGene clusters of homologous genes and sequences that cite the current articles. These are references on the Gene and sequence records in the HomoloGene entry.
Nucleotide (RefSeq)
NCBI nucleotide Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
Protein (RefSeq)
NCBI protein Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
Protein Clusters
Clusters of related proteins from the Protein Clusters database that cite the current articles. Sources of references in Protein Clusters include the associated Gene and Conserved Domain records as well as NCBI added citations.
Taxonomy via GenBank
Taxonomy records associated with the current articles through taxonomic information on related molecular database records (Nucleotide, Protein, Gene, SNP, Structure).
UniGene
UniGene clusters of expressed sequences that are associated with the current articles through references on the clustered sequence records and related Gene records.
Domains
Conserved Domain Database (CDD) records that cite the current articles. Citations are from the CDD source database records (PFAM, SMART).
Protein
Protein translation features of primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
GEO Profiles
Gene Expression Omnibus (GEO) Profiles of molecular abundance data. The current articles are references on the Gene record associated with the GEO profile.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Cell cycle, CDKs and cancer: a changing paradigm.
Cell cycle, CDKs and cancer: a changing paradigm.
Nat Rev Cancer. 2009 Mar ;9(3):153-66.

PubMed
Laparoscopic excision of the cystic lymphangioma occurred in the lesser omentum:...
Laparoscopic excision of the cystic lymphangioma occurred in the lesser omentum: report of a case and review of literature.
Surg Laparosc Endosc Percutan Tech. 2009 Feb ;19(1):e11-4.

PubMed
IL-17 secreted by tumor reactive T cells induces IL-8 release by human renal can...
IL-17 secreted by tumor reactive T cells induces IL-8 release by human renal cancer cells.
J Immunother. 2009 Feb-Mar ;32(2):109-17.

PubMed
Would you like your colloid straight or with a twist of an anti-inflammatory ant...
Would you like your colloid straight or with a twist of an anti-inflammatory antioxidant?
Crit Care Med. 2009 Mar ;37(3):1133-4.

PubMed
Jivaro tsantsas or shrunken head: an expertise of authenticity evaluation.
Jivaro tsantsas or shrunken head: an expertise of authenticity evaluation.
Am J Forensic Med Pathol. 2009 Mar ;30(1):72-4.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Cell cycle, CDKs and cancer: a changing paradigm.

Source

Abstract

Publication Types, MeSH Terms, Substances, Secondary Source ID

Publication Types

MeSH Terms

Substances

Secondary Source ID

LinkOut - more resources

Full Text Sources

Medical

Supplemental Content

Save items

Related citations in PubMed

Cited by over 100 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information