J Clin Gastroenterol. 2009 Aug;43(7):672-5.

Prolonged intrahepatic cholestasis and renal failure secondary to anabolic androgenic steroid-enriched dietary supplements.

Source

Division of Gastroenterology and Hepatology, Henry Ford Hospital, Detroit, MI, 48202, USA.

Abstract

The illegal enrichment of anabolic androgenic steroids in over-the-counter dietary supplements is well documented, but the health consequences have not been widely recognized. Three recent reports document cholestatic jaundice and nephropathy due to these compounds. We present 3 additional cases of anabolic androgenic steroid-enriched dietary supplement-induced hepatotoxicity and 1 case of renal failure, and we review the literature and the relevant features of this growing health concern. Recognition of this entity could obviate the need for invasive diagnostic testing and hospitalization and facilitate diagnosis and appropriate counseling.

PMID:: 19238093; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Case Reports

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Medical

Supplemental Content

Related citations

Hepatotoxicity associated with dietary supplements containing anabolic steroids. [Clin Gastroenterol Hepatol. 2007]
Hepatotoxicity associated with dietary supplements containing anabolic steroids.
Kafrouni MI, Anders RA, Verma S. Clin Gastroenterol Hepatol. 2007 Jul; 5(7):809-12. Epub 2007 May 16.
Androgenic/anabolic steroid-induced intrahepatic cholestasis: a review with four additional case reports. [J Okla State Med Assoc. 1994]
Androgenic/anabolic steroid-induced intrahepatic cholestasis: a review with four additional case reports.
Gurakar A, Caraceni P, Fagiuoli S, Van Thiel DH. J Okla State Med Assoc. 1994 Sep; 87(9):399-404.
Review Severe cholestasis and renal failure associated with the use of the designer steroid Superdrol (methasteron): a case report and literature review. [Dig Dis Sci. 2009]
Review Severe cholestasis and renal failure associated with the use of the designer steroid Superdrol (methasteron): a case report and literature review.
Nasr J, Ahmad J. Dig Dis Sci. 2009 May; 54(5):1144-6. Epub 2008 Aug 22.
Anabolic steroid hepatotoxicity: lessons to be learnt? [Aust N Z J Med. 1993]
Anabolic steroid hepatotoxicity: lessons to be learnt?
Forbes GM, Bramston BA, Collins BJ. Aust N Z J Med. 1993 Jun; 23(3):309-10.
Review Acute kidney injury due to anabolic steroid and vitamin supplement abuse: report of two cases and a literature review. [Int Urol Nephrol. 2009]
Review Acute kidney injury due to anabolic steroid and vitamin supplement abuse: report of two cases and a literature review.
Daher EF, Silva Júnior GB, Queiroz AL, Ramos LM, Santos SQ, Barreto DM, Guimarães AA, Barbosa CA, Franco LM, Patrocínio RM. Int Urol Nephrol. 2009; 41(3):717-23. Epub 2009 Apr 23.

See reviews... See all...

Cited by 1 PubMed Central article

Potentially harmful advantage to athletes: a putative connection between UGT2B17 gene deletion polymorphism and renal disorders with prolonged use of anabolic androgenic steroids. [Subst Abuse Treat Prev Policy. 2010]
Potentially harmful advantage to athletes: a putative connection between UGT2B17 gene deletion polymorphism and renal disorders with prolonged use of anabolic androgenic steroids.
Deshmukh N, Petróczi A, Barker J, Székely AD, Hussain I, Naughton DP. Subst Abuse Treat Prev Policy. 2010 Apr 29; 5:7. Epub 2010 Apr 29.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Prolonged intrahepatic cholestasis and renal failure secondary to anabolic andro...
Prolonged intrahepatic cholestasis and renal failure secondary to anabolic androgenic steroid-enriched dietary supplements.
J Clin Gastroenterol. 2009 Aug ;43(7):672-5.

PubMed
Sex differences in vulnerability to developmental spatial learning deficits indu...
Sex differences in vulnerability to developmental spatial learning deficits induced by limited binge alcohol exposure in neonatal rats.
Neurobiol Learn Mem. 1995 Nov ;64(3):265-75.

PubMed
Prenatal alcohol and offspring development: the first fourteen years.
Prenatal alcohol and offspring development: the first fourteen years.
Drug Alcohol Depend. 1994 Oct ;36(2):89-99.

PubMed
Brief but efficient: acute HIV infection and the sexual transmission of HIV.
Brief but efficient: acute HIV infection and the sexual transmission of HIV.
J Infect Dis. 2004 May 15 ;189(10):1785-92. Epub 2004 Apr 28 .

PubMed
Translocation of p53 to mitochondria is regulated by its lipid binding property ...
Translocation of p53 to mitochondria is regulated by its lipid binding property to anionic phospholipids and it participates in cell death control.
Neoplasia. 2010 Feb ;12(2):150-60.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to: